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As GSTP1 knockdown significantly increased cisplatin and carboplatin chemosensitivity in A2780 cells, we further investigated whether GSTP1 knockdown in the related platinum-resistant A2780DPP cell line (Behrens et al, 1987) could re-sensitise these drug-resistant cells to platinum-based chemotherapy

LPA stimulates cancer cell proliferation primarily by regulating key cell cycle genes in many different cancers, although receptor engagement varies

Lancet 372, 20232030.10.1016/S0140-6736(08)61598-6 95 MakadiaH

doi: 10.1038/sj.jhh.1001416 Vanderah TW (2024): Cholinoceptor-Blocking Drugs

Scheduled breaks or cyclic protocols are often used to reduce that risk, but individual response is highly variable