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To reconcile the opposite effects of V-ATPase dysfunction on autophagy flux in nutrient-rich versus starvation medium, we reasoned that dysfunction of the V-ATPase may have dual roles in autophagy regulation: On the one hand, it hampers vacuolar hydrolytic activities (but vacuolar proteases such as Pep4 are still partially active)

Increased lipolysis in adipose tissues is associated with elevation of systemic free fatty acids and insulin resistance in perilipin null mice

has received honoraria and non-financial support from Amgen, Bristol Myers Squibb/Celgene, Janssen, and Sanofi, and non-financial support from Oncopeptides

Conclusion Vitamin B12 is a cornerstone in maintaining numerous bodily functions, from energy production to neural health

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