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While sub-chronic exposure to PG/nicotine promote nAChR7-dependent increased levels of different cytokines and chemokines in the bronchoalveolar lavage fluid (BALF) such as IL-1, IL-2, IL-9, interferon (IFN), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1/CCL2) and regulated on activation, normal T cell expressed and secreted (RANTES/CCL5), the enhanced levels of IL-1, IL-5 and TNF were nAChR7 independent

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According to a study by Nasrallah and Garg (2023) titled Studies Pertaining to the Emerging Cannabinoid Hexahydrocannabinol (HHC), published in ACS Chemical Biology , HHC interacts with the same cannabinoid receptors as THC but demonstrates a slightly altered binding affinity due to its unique chemical structure