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IGF-1 blocks transient A-type K + currents and increases high-voltage-activated Ca 2+ currents, while keeping low-voltage-activated Ca 2+ and Na + current constant [75]

Continuous inflammation caused by UV radiation or other damage can further promote oxidative stress, stimulate the proliferation of skin immunosuppressive cells, and produce early cancer cell growth factors, which damage cellular biomolecules and accelerate skin aging

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10.3390/molecules26144149 294 ZhangJ.LiangF.ChenZ.ChenY.YuanJ.XiongQ.et al (2022c)