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Figure 1 Regulation of SLC7A11 at the Molecular Level The expression of SLC7A11 can be modulated by various stress-inducing conditions (metabolic stress, amino acid starvation, genotoxic stress, hypoxia, viral infection) through transcription factors, epigenetic regulators, protein stability, interaction with other proteins, post transcriptional regulation, post-translational regulation, and transporter activity ( Figure 1 ) ( SLC7A11 which allow the cells to adapt and respond to stress ( In addition to the transcriptional regulation of SLC7A11 under conditions of cell stress, SLC7A11 is also regulated via post-transcriptional mechanisms ( SLC7A11 gene and is associated with the transcriptional repression of SLC7A11 and ferroptosis induction

2014;15(10):e43546