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The extreme cold triggers a surge of catecholamines, hormones that act as neurotransmitters, activating the body's fight-or-flight response, Brecka explained

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

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