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Notably, phosphorothioates and dithioates are often pro-toxicants, requiring oxidative desulfuration by hepatic cytochrome P450 enzymes to convert into active oxon forms (e.g., parathion paraoxon), which are potent acetylcholinesterase inhibitors

It further explores the potential of natural metabolic modulators in improving the tumor immune microenvironment and enhancing immunotherapy sensitivity

Furthermore, BHB treatment suppresses oxidative stress in cardiomyocytes and prevents ischemia/reperfusion injury in the mouse heart by reducing ROS production, attenuating mitochondrial swelling, and partially restoring mitochondrial membrane potential (75)

HLA sequencing was performed for DILIN patients while HLA allele imputation from genotype data was carried out for matching population controls

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