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As novel forms of systemic therapies have entered clinical practice, new limitations have come to light, including the unmet needs of understanding how to optimize the benefit of personalized therapies by overcoming primary and secondary drug resistance, understanding the immunobiology of CCA to implement biomarkers for the selection of patients who would benefit from immune-checkpoint inhibitors, and refining immunotherapeutic strategies through the targeting of diversified immune populations and developing more personalized vaccine strategies

doi: 10.1038/s41589-021-00915-2

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The oxidized form, vitamin K epoxide, is converted back into hydroquinone via a two-step reaction