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Wilimitis, D

Bacteriostatic water for injection has an extra preservative agent added into the water called benzyl alcohol (BnOH)

Accumulating evidence highlights that MAMs are associated with the pathological relevance observed in both FALS and sporadic ALS, such as mitochondrial impairment, disrupted Ca 2+ homeostasis, improper protein folding, and the ER stress response

RK There are many classes of targets currently under investigation, some of which are listed in the Table

VPS35 mutation is not sufficient to cause neuroinflammation, as D620N knock-in mice do not exhibit increased astrogliosis or microgliosis [172, 173], but D620N exacerbates microgliosis secondary to MPTP treatment [172]