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In previous work, we used high-throughput digitalized IHC analysis with a machine learning-based tumor/stroma classifier, and demonstrated that glutathione (GSH) dynamic proteins, including glutaminase-1 (GLS), were associated with NAC resistance in MIBCs 14

Notably, the mechanisms that link synaptic dysfunction with the manifestations of CAs can be explained by disruption of the internal models. The latter can be divided into three levels

For glutathione, the harsh environment of the stomach often dismantles the molecule, leaving only individual amino acids that do not provide the same targeted benefits

Loss of tolerance towards self-antigens associated with regulatory T cell (Tregs) dysfunction is central to AIH pathogenesis [87]

However, curative treatments for this pathology are still lacking and the response rates to this and other treatments are often incomplete [115]