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As a proof of concept, the assembly of functional AuNPs in a tumour-selective manner can mimic BiTE for precise combinational immunotherapy

Norepinephrine is normally released from nerve terminal vesicles in response to sympathetic nerve action potentials, and is lowered through presynaptic receptors by the 1 AR antagonists

However, frequent dosing into ocular tissues may occur because of slow drug release from polymeric nanoformulations over a long period, which may harm the ocular tissues or trigger immune responses