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doi: 10.1038/ni.3107 102 MattiolaI

This oxidative burden impairs mitochondrial function and depletes antioxidant defenses, creating a self-propagating cycle of damage (Oyagbemi et al

11 : e0150205

Additionally, dosing at 20 mg/kg body weight or greater resulted in mild to severe fundic lesions on ophthalmologic examination (change in color of the fundus, central or generalized retinal degeneration), abnormal electroretinograms (including blindness), and diffuse light microscopic changes in the retina