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Methylmalonic acid is considered the most specific functional biomarker and a sensitive indicator for B12 deficiency, as noted earlier

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The warning signs of a vitamin B12 deficiency A pale yellow tinge to your skin A sore and red tongue (glossitis) Mouth ulcers Pins and needles (paraesthesia) Changes in the way that you walk and move around Disturbed vision Irritability Depression Changes in the way you think, feel and behave A decline in your mental abilities, such as memory, understanding and judgement (dementia)

But it can also be combined with surgical fat grafting for volume, as seen in Dr