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The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia

Research has shown that ischemia-reperfusion injury leads to increased expression of ER stress-associated proteins such as p-PERK, p-eIF2, ATF4, and CHOP in the penumbra and ischemic cortex (Wu et al., 2013)

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These gaps underscore the need for more rigorous approaches, including gene-editing technologies, multi-omics analysis, and in vitro and in vivo models to elucidate the molecular mechanisms by which natural products may regulate autophagy and to assess their potential translational relevance in ovarian function preservation

The absence of mature, peer-reviewed results from most trials underscores the nascent stage of this field