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ITPP works by reducing hemoglobins oxygen-binding affinity, increasing the oxygen-release capacity of red blood cells (156)

Table 3 How to prevent or delay progression of diabetic nephropathy Aim for a near-normal glycaemia, and this should be achieved as soon as possible Blood pressure should be mantained at less than the 95th centile for age Improve blood lipids levels Discourage excessive nutritional protein intake: not more than 1.0-1.2 g/Kg body weight/day Encourage physical exercise Strongly discourage smoking Angiotensin converting enzyme inhibitors (ACEI) Angiotensin II receptor blockers (AIIRA) Retinopathy Diabetic retinopathy (DR) is the major cause of new cases of blindness in adults

J Clin Endocrinol Metab 2005

A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability