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This production is induced by cytokines, which stimulate cells such as fibroblasts and osteoblasts, and can cause indirect tissue damage [132]

the present invention also relates generally to novel proteins, and fragments thereof, as well as nucleic acids which encode these proteins, and methods of making and using these proteins in diagnostic, prophylactic and therapeutic applications

doi: 10.1111/j.1747-4949.2008.00222.x

The response to PDE5 inhibitors is reduced as the low testosterone levels reduce expression of both the nitric oxide synthase gene and the PDE5 gene and downregulate PDE5 enzyme

Lopez de las Hazas et al., 2021)