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Increased demand for NAD(+) relative to ATP drives aerobic glycolysis

LS decreases glycolysis and enhances mitochondrial biogenesis, preventing vascular damage

Restored myocardial Sirt1 mRNA and protein expression relative to untreated diabetic mice

Additional differences include variations in fat globule size, mineral content (e.g., higher calcium and phosphorus levels in A1 milk), and fatty acid profiles, with A2 milk having smaller fat globules and higher polyunsaturated fatty acid (PUFA) content [1, 39]

in situ profiling of transcriptomes encompassing ~20,000 genes within tissue samples, using platforms such as those from Illumina, 10x Genomics, and NanoString