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Iron deficiency Iron deficiency is linked to low glutathione levels, as are many other health conditions

24 Secondly, activated Akt phosphorylates forkhead box O1 (FOXO1), a transcription factor upregulating gluconeogenesis rate-limiting enzyme such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), and translocate it from nucleus to cytoplasm, which inactivate its transcriptional activity, thus inhibiting gluconeogenesis

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The fingers and hands soon became stiff and immobile, as did the legs and feet

doi: 10.1038/nrgastro.2010.97