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Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity

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Supported by progress in targeted delivery systems, these multifaceted mechanisms underscore its significant potential for clinical application (80)

The cellular experiments found that crocin skewed the polarization of glial BV-2 cells from the inflammatory M1 phenotype to the M2 phenotype by inhibiting the NF-kB and NLRP3 signaling pathway (96)