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A.JayakumarT.SheuJ

(2009) provided the foundation for the division of asthma into T2-high and T2-low endotypes based on gene expression patterns, identifying a T2-high gene signature characterized by elevated expression of IL-5, IL-13, and periostin in bronchial biopsies, which correlated with eosinophilic inflammation and response to corticosteroids

This regulatory mechanism ensures that cancer cells are capable of maintaining iron homeostasis and their proliferative capacity despite oxygen deprivation