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In the rat model of neuropathic pain induced by CCI, Fer-1 upregulates GPX4 expression, downregulates ACSL4 expression, and decreases the content of iron in the spinal cord, while erastin has the opposite effect

Additionally, lacosamide, an approved drug for treating epilepsy, has also been reported to induce histone hyperacetylation via reductions of HDACs protein expressions, enhancement of histone acetyltransferase or HDAC inhibition by its metabolites [48, 49]