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Muller HL, Emser A, Faldum A, Bruhnken G, Etavard-Gorris N, Gebhardt U, et al

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

In MDR NCI/ADR-RES ovarian and doxorubicin-resistant MCF-7 cells, MCJ deficiency was found to be responsible for maintaining the drug efflux pumps and supporting the resistance in them thus highlighting MCJ as a therapeutic candidate [227, 228]