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Furthermore, we revealed that co-administration of EPI and F--DDB-derivative (ip, once every other day for 14 days) significantly increased the therapeutic efficacy of EPI (2.0 mg/kg) or F--DDB-derivative (20.0 mg/kg) in mice harboring MDA-MB-468 cell xenografts without additional cardiotoxicity compared to that in EPI monotherapy group

On paper, one peptide favouring angiogenesis and cytoprotection while the other favours cell migration and actin dynamics looks complementary which is why researchers find the pairing interesting

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2.4 Muscle proteome Frozen gastrocnemius tissue from the right hindlimb was crushed with a pestle and placed in homogenization buffer (1% Triton X-100, 50 mM HEPES, 12 mM Na pyrophosphate, 100 mM NaF, 10 mM EDTA, protease inhibitor, phosphatase inhibitor) with a stainless-steel bead

The peptide that does penetrate stays mostly local, limiting systemic effects