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40 In subsequent studies, Edelbium and co-workers, 42 used occludin-null mice to further demonstrate defective accumulation and migration of intraepithelial lymphocytes within their intraepithelial compartment (vs

The majority of renoprotective claims derive from rodent models (primarily db/db mice, streptozotocin-induced diabetes, or high-fat diet models), which exhibit fundamental differences from human DKD in gut microbiota composition, metabolic kinetics, and disease progression timelines

Consequently, the importance of SPMs as endogenous compounds produced in quantities adequate for exerting an anti-inflammatory effect in vivo remains speculative

doi: 10.1371/journal.pbio.3000492