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However, combining with other SIRT1 activators (resveratrol, pterostilbene) or AMPK activators (metformin, berberine) has not been systematically studied

10.1016/j.foodchem.2014.01.071 471

The results showed that BP-QDs induced LDH (an indicator of cell membrane integrity) leakage from A549 and Beas-2B cells in a concentration-dependent manner (Ruan et al., 2021)

MMR removes the base opposite to the adduct, which may cause a new mismatch, starting the pathway again and leading to the so-called futile cycle, generating double stranded breaks