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Furthermore, the functional enrichment analyses indicated that the differentially expressed genes (DEGs) between the mild and severe groups were significantly related to redox homeostasis (GO:0045454, GO:0006979, hsa05208, R-HSA-9818027, and R-HSA-3299685), cytokine signaling (GO:0034097, R-HSA-1280215, and R-HAS-449147), ferroptosis (hsa04216), and ferroptosis-related pathways (hsa04390 and hsa04310) (Fig

On the other hand, some data indicate that a high ascorbic acid (1 mM) concentration may lead to a disturbed Keap1/Nrf2/ARE pathway activation [85]

242 Astragaloside IV inhibits the PI3K/Akt/mTOR pathway by upregulating miR-155 expression, thereby preventing apoptosis and enhancing autophagy to alleviate myelin damage in Schwann cells and improve neurological function in DPN rat models

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