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Mn also activated NF-B to increase YY1 expression, which in turn, repressed GLT-1 (EAAT2) in astrocytes ( 3.1.7 PPARs PPARs are TFs with three isotypes, PPAR-, PPAR-/, and PPAR-, playing a role in development, proliferation, differentiation, lipid and energy metabolism, and survival ( 3.2 Mns intracellular target proteins Intracellular communications such as signaling pathways are dysregulated in Mn-induced toxicity

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