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Patented: see www.takeda.com/en-us/patents Patient Information ADYNOVATE (ah-DYE-noh-vayt) [Antihemophilic Factor (Recombinant), PEGylated] This leaflet summarizes important information about ADYNOVATE

A large randomized trial in older adults found no effect of EPA and DHA on cognitive function, and the broader trial record shows little benefit in cognitively healthy people or in established Alzheimers, with a possible signal in early cognitive impairment and in people who do not carry APOE4