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387 Thus, the administration of psilocybin can rapidly and persistently induce neuronal dendritic remodeling in the medial frontal cortex of mice, and the psilocybin-induced newly formed dendritic spines can successfully transform functional synapses, suggesting that synaptic rewiring may also be one pharmacological mechanism of the rapid antidepressant effects of psilocybin

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Moreover, in hypoxic-ischemic encephalopathy (HIE), elevated ECAR, an indicator of glycolysis, increases Pan Kla and cGAS lactylation and shifts microglia to the M1 phenotype, releasing pro-inflammatory factors such as IL-1, iNOS, and TNF- in microglia stimulated by OGD