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10.3389/fimmu.2024.1361519 9 FlossmannO.BaconP.de GrootK.JayneD.RasmussenN.SeoP.et al (2007)

On the one hand, ROS, as a second messenger, can activate MAPK or NF-B pathway and mediate granulocyte macrophage colony-stimulating factor (GM-CSF) production (224), which can interact with RNAKL and M-CSF to promote osteoclast differentiation (225)

FSP1 (formerly AIFM2) functions at the plasma membrane as an NAD(P)H-dependent oxidoreductase that reduces ubiquinone (CoQ10) to ubiquinol, thereby trapping lipid radicals and preventing propagation of phospholipid peroxidation independently of GPX4 [60]