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Splenic sequestration occurs when the spleen enlarges (for example, due to cirrhosis of the liver or certain types of leukemia) and captures, or sequesters, more platelets from the circulation than normal

Although the first peptide-based drugs appeared as early as the mid-twentieth century, it is only in recent decades that the pharmaceutical industry has actively begun developing peptide-based medications

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Mascitti M, Santarelli A, Sartini D, Rubini C, Colella G, Salvolini E, Ganzetti G, Offidani A, Emanuelli M (2019) Analysis of nicotinamide N-methyltransferase in oral malignant melanoma and potential prognostic significance