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Three researchers evaluated the risk of bias in eligible studies manually and independently and reached a consensus

The C-terminal tail of c-MET binds to numerous Src homology 2 domain containing effectors, such as PI3-K, the non-receptor kinase Src, the growth factor receptor bound protein 2 (GRB2) and SH2 domain-containing transforming protein (SHC) adaptors SHP2 (also known as PTPN11

Primarily, weight management and blood sugar regulation, with additional research exploring cardiovascular outcomes through the CagriSema combination

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Another study reported that weekly 50,000 IU vitamin D for 8 weeks, followed by daily oral supplementation with 2,500 mg calcium carbonate (1,000 mg elemental calcium) plus 9.68 mg cholecalciferol (880 IU vitamin D) for 3 months, significantly elevated SHBG levels and decreased TT, FT, and ADMA concentrations, effectively improving menstrual regularity and alleviating hirsutism in non-obese PCOS patients (116)