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Outcome and Management Elucidating the cause of liver test abnormalities in patients with sickle cell disease on therapies to prevent vaso-occlusive crises is difficult, as they are susceptible to several forms of liver injury including acute viral hepatitis, hemosiderosis, gallstone disease, congestive hepatopathy and ischemic liver injury from hepatic sickling crises

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Altogether it can be concluded that an observed elevation of cobalamin in blood merits a full diagnostic work up to assess the presence of disease

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