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Human Studies Human data remain limited, and most studies are small, single-center, or use copper peptide formulations combined with other ingredients (which makes it hard to isolate GHK-Cu's specific contribution): A 2016 Lee et al

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Furthermore, p53 indirectly increases GSH synthesis under serine and glycine starvation conditions, as p53 arrests the cell cycle by inducing p21, and de novo-synthesized glycine is utilized for GSH, but not purines (31)

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10.1016/j.bbabio.2018.04.001 43 HeY.ZhengZ.LiuC.LiW.ZhaoL.NieG.et al (2022)