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doi: 10.1016/S0140-6736(84)91816-6 4

76%, p-value 0.05)

In sum, although the study design and interpretation of clinical relevance in the findings of these studies have been debated (157, 158), they have not provided convincing enough evidence of a significant, sustained treatment effect for the Infectious Diseases Society of America (IDSA) to recommend additional antibiotics in their guidelines (159, 160), and the risk of antibiotic resistance at the population level with long-term, untargeted use of antibiotics are often cited as significant concerns (161)