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Laboratories studying cartilage matrix biology, chondrocyte proliferation and differentiation, and growth factor signalling in musculoskeletal research models have incorporated this fragment as an experimental variable representing an expanding research frontier beyond its primary metabolic applications

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Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination

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