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Research has focused on characterizing NIs in PD/DLB brains, but there is less understanding of the GCIs in the MSA brain, partly due to the lower incidence of MSA (1.6 cases per 100,000 individuals over the age of 40) than PD/DLB [4, 44, 55, 62]

-1-microglobulin, which is involved in detoxification

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Measurement of ceramide concentrations by LC-MS/MS-MRM Standards of C16:0-, C22:0-, C24:1- and C24:0- ceramides plus C16:0- and C24:0-dihydroceramides were diluted with methanol to prepare calibration solution mixtures with concentrations of 2, 1, 0.5, 0.2, 0.1, 0.05, 0.02 and 0.01 pmol/l of each component

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