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For instance, Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (in PD, AD, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (PD), is a stress marker (temporal lobe epilepsy), and also protects cells from cerebral ischemic injury

Encapsulating or conjugating sodium channel blockers into nanocarriers allows for enhanced drug bioavailability, solubility, and target-specific delivery, resulting in better therapeutic effects

Small-bowel bacterial overgrowth may elevate serum MMA concentrations due to the production of high levels of propionic acid (the precursor of MMA) by bacteria

Metabolites secreted by Bifidobacterium infantis Y1, one of the components of the probiotic product VSL#3, leads to an increase in expression of ZO-1 and occludin while reducing expression of claudin-2 leading to enhanced effects on transepithelial resistance and altered ion secretion [114]