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Activated Th17 cells secrete IL-17A, IL-17F, and IL-22, all of which have potent effects on keratinocytes, stimulating them to produce inflammatory mediators (e.g., IL-1, IL-6, TNF-), chemokines (e.g., CCL20, CXCL1-3), and antimicrobial peptides (e.g., -defensins and S100 proteins)

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