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The efficacy and safety of NT-501 have been assessed in two 1-year Phase II randomized clinical trials in patients with early and advanced retinitis pigmentosa (RP), as well as a 6-month Phase I non-randomized clinical trial in RP patients

FEBS Lett 84(1):125128

Their method involved adding SRBCs to mouse spleen cells in Petri dishes and then charting the formation of plaques which signified the emergence of cells that secreted antibodies to the SRBCs (Mishell, Dutton)