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Thats when their cells arent responding as well to insulin as they used to

Antioxidants (2018) 7(12):177

Reduced Annexin A1 secretion by ABCA1 causes retinal inflammation and ganglion cell apoptosis in a murine Glaucoma model

Such oxidations are in direct competition with glutathione reductase and ABC transporters which usually maintain very low GSSG concentrations under physiological conditions 5,7,62,63,64