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In cancer cells, the tumor suppressor p53 has a crosstalk with NIK, in which p53 inhibits NIK expression through induction of a miRNA, miR-34b, that targets the coding sequences of Map3k14 to suppress its mRNA expression [52]

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Furthermore, an in vitro study showed that 2,3-DPG production of erythrocytes incubated with inosine and pyruvate was augmented by the addition of phosphate at a level of 4 mM (20)