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The name RAS originates from RaS viruses, where viral oncogenes were first identified in the 1960s and 1970s.1 2 A major breakthrough came in 1982, when three independent groups used NIH 3T3 mouse embryonic fibroblast transfection assays to show that human tumoursmost notably bladder carcinomascarry transforming genes homologous to the viral ras oncogenes of the Harvey and Kirsten sarcoma viruses.35 These findings were soon extended to additional malignancies, and mutated HRAS and KRAS were confirmed as oncogenic drivers in human bladder, lung and colorectal cancers (CRC).69 This provided the first definitive evidence that non-viral human cancers can result from activating point mutations in host-intrinsic proto-oncogenes

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Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L

2 The usefulness of applying evolutionary principles to medicine becomes apparent when we view the human body as what it truly is, a product of natural selection, with a particular focus on our reproduction, and not our health or well-being, being favoured by evolution

Adipocyte-derived hormones, notably leptin and adiponectin, are integral to the development of obesity