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Statistics Statistics were run using GraphPad Prism (v7.05) unless specified otherwise

Not for clinical or therapeutic use

Shared Risk Factors Aging and reduced absorption capacity Sedentary indoor lifestyle Limited sun Vegetarian or restrictive diets Gastrointestinal disorders (gastritis, IBS, celiac disease) Long-term use of proton pump inhibitors or metformin And when both are low, the effects compound

Comments submitted after July 9 but before the July 22 docket closure will still be considered by FDA, but will not go directly to the Committee

It has been found that the addition of vitamin B 12 may provide a benefit in pain improvement