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Conclusion: Decreased serum albumin level and prolonged prothrombin time along with high baseline HBV DNA levels were predictive of the hepatitis flare and initiation of NA therapy in HBeAg-negative grey zone CHB patients

Chinese herbal medicine Xueshuantong enhances cerebral blood flow and improves neural functions in Alzheimers disease mice

Protective effects of Indian spice curcumin against amyloid-B in alzheimers disease

144 Liu et al

It enables large endogenous neuropeptides, enzymes, growth factors, transferrin and hormones, among the others, to penetrate the BBB harnessing their specific receptors that are highly expressed on the luminal side of endothelial as widely discussed in (Saraiva et al., 2016) and further explained, with representative examples, in section Preclinical achievements of polymeric nanoparticles-mediated drug delivery in Alzheimers disease. The same strategy can also be exploited to deliver drugs against AD into the brain, using surface-modified polymeric NPs as further described in section Polymer functionalization strategies, or even circulating exosomes (Wang et al., 2019)