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, VHL deletion) or reactive oxygen species (ROS) under normoxia, compounded by tumor vascular abnormalities inducing regional hypoxia ( Figure 1 )

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Although the included studies were conducted in rodent models, Met has long been (1950s) used clinically for diabetes and shows benefits in improving testosterone levels and sperm parameters in men []

Another important outcome was represented by a significant upregulation of genes linked to axonal growth, to the cAMP signaling pathway, and to myelin function

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