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The enzyme contains flavin adenine dinucleotide (FAD) as a prosthetic component, and as a result, normal enzyme activity is dependent on the dietary availability of riboflavin

Immunohistochemical analyses of coronal brain sections 12 h after compression injury (bottom) shows that cell death (red) extends several layers into the neocortex

Colas J, Faure G, Saussereau E, Trudel S, Rabeh WM, Bitam S et al

Reassuringly, the loss of FH was also associated with the activation of an antioxidant response similar to that observed in Fh1-deficient cell lines (Supplementary Fig 5b)