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Natural melanin samples were purified from human hair by enzymatic proteolytic procedures 9

Results: A total of 116 SNPs were selected as valid instrumental variables to estimate the causal association of serum total bilirubin on cholelithiasis, and causal association between genetically determined serum total bilirubin and cholelithiasis was demonstrated [beta = 0.10

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[0285] The term "anti -tumor effect" as used herein, refers to a biological effect that can be manifested by a decrease in tumor volume, a decrease in the number of tumor cells, a decrease in the number of metastases, an increase in life expectancy, or amelioration of various physiological symptoms associated with the cancerous condition

This finding is consistent with the work of Hammad et al., who demonstrated that activation of PPAR- promotes DC tolerance and impairs DC maturation, thereby reducing eosinophilic airway inflammation in mouse models of asthma[87]