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A simplistic underlying hypothesis is that mtDNA polymorphisms might impact energy metabolism during both a resting state, by decreasing the ability to preserve transmembrane ion gradients and hence predisposing to a hyperexcitability state, and during stress circumstances by failing to mount a greater energy supply for increased demand

Another observation poorly explained by our model is that in many sufferers, CVS episodes are regular by the calendar, both in terms of both time of the day regarding symptom onset (circadian cycle), and for time of the month/year regarding episode intervals (infradian cycle) (3, 71, 102104)

Power calculation for the associations of genetically predicted l-carnitine and acetyl-carnitine with cardiovascular disease and its risk factors

UK Biobank is a large, ongoing, prospective cohort study, with currently a median follow-up time of 11.1 years [29]