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Further analysis using metanomeSeq revealed that the relative abundance of Escherichia-Shigella , Enterococcus , Clostridium_sensu_stricto_1 strain , Prevotellaceae_NK3B31_group , and [Eubacterium]_xylanophilum_group increased significantly in PSO model mice, while Muriaculum , Ruminococcus , Oscillospiraceae_NK4A214_group , Parabacteroides and Odoribacter decreased significantly ( Figure 3H )